What it is
DSIP is a peptide made of 9 amino acids. It is made in a lab. Swiss researchers first found it in 1977 in the blood of rabbits that were in deep sleep. It is named for delta sleep, the deepest stage of sleep. Its full job in the body is still not known. It leaves the blood in minutes. Other names: Delta Sleep-Inducing Peptide, Delta Sleep Peptide.
What researchers study it for
- Deep sleep in animals and people
- Insomnia
- Stress hormones
- Pain in animals
What the studies found
1. An early study reported better sleep in people with insomnia.
A 1981 study gave DSIP by IV to people with long-term insomnia. Their sleep was measured with brain wave tests in a sleep lab. Sleep measures improved. The study was small and has not been repeated in a modern trial.
2. Results from the first 7 years were mixed.
This 1984 review looked at all DSIP research since 1977. Early studies showed large increases in deep sleep. Later studies gave different results depending on the animal, how it was given, and how well the subjects slept to begin with. The review also noted that effects lasted longer than DSIP stayed in the blood.
3. It did not lower stress hormones in people.
A 1995 controlled study gave people DSIP, then triggered a rise in the stress hormones ACTH and cortisol. The rise was triggered two ways: with a hormone signal called CRH and with a meal. DSIP did not change either rise. This does not match older animal studies that called DSIP an anti-stress peptide.
How much research exists
Most research is from the 1970s to the 1990s. Human studies are small and few. No modern controlled trial has been published.
Facts
- Formula: C35H48N10O15
- Weight: 848.8 g/mol
- CAS number: 62568-57-4
- Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
- Time in the blood: 7 to 8 minutes
- Storage: freeze the dry powder. Keep mixed solution in the fridge.
Legal status
Not approved by the FDA or any other agency for human use. Banned in sports by WADA under section S0, which covers drugs not approved for human use.
For research use only. Not for human use. Nothing here is medical advice.